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KMID : 0616120100410030210
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 3 p.210 ~ p.215
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Single Oral Toxicity Study on the Polysaccharide Fraction of Pueraria lobata in Rats
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Chang Bo-Yoon
Cho Hyoung-Kwon
Jun Ki-Young
Hur Jong-Moon
Park Hyun
Kim Sung-Yeon
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Abstract
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Acute toxicity on the polysaccharide fraction of Pueraria lobata was examined using male and female Sprague-Dawley rats. The polysaccharide fraction of Pueraria lobata was orally administered at a dose of 5 mg/kg, 50 mg/kg, 500 mg/kg, 2,000 mg/kg and 5,000 mg/kg and observed for two weeks. No mortality and abnormal clinical signs were observed at the doses used. There were not any significant differences in parameters of blood biochemical values and urinalysis by the treatment of test material. All rats were appeared to be healthy and normal throughout the observation period. Also there was no difference in net body weight gain and gross pathological findings among the groups rats treated with different doses of the polysaccharide fraction with Pueraria lobata.
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KEYWORD
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Acute oral toxicity, Polysaccharide fraction of Pueraria lobata, Rats
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